Nandrolone Decanoate: Use, Abuse and Side Effects
Pro-aggregatory effects on platelets because of high dosages of androgens could be related to a decrease in cycloxygenase activity 68. Most of these alterations could lead to an increased thrombosis risk or atherosclerotic effects on vessels 42,69. Cases of women with ovarian follicles maturation failure, uterus, clitoris, vagina, and mammary gland hypertrophy, with hormonal disorders, confirmed by experiments on animals, have been reported in the literature. ND decreased the serum level of follicle-stimulating hormone (FSH), Luteinizing hormone (LH), progesterone and estrogen 52. ND also promoted histological alterations in female genital organs in a dose-independent manner, despite recovery from treatment 33,53.
- While it offers various benefits, it also comes with potential side effects and risks.
- However, in the U.S. the only pharmaceutical grade available is imported or manufactured by compounding pharmacies with the Decanoate version being almost the only version ever found.
- There are a few side effects that could affect people with certain genetic traits that aren’t too common, but for most healthy males over the age of 18, you’re going to be perfectly fine as long as you use the compound in a responsible manner.
- As transfeminine people also have prostate glands, the weak effects of nandrolone in the prostate are potentially of relevance to us as well.
- Due, in part, to these adverse effects, and the development of newer and more effective therapies to treat osteoperosis (i.e., bisphosphonates), nandrolone never gained traction as an effective clinical adjunct for this indication.
What were the side-effects while using Nandrolone Decanoate 25mg Injection?
Nandrolone, or 19-nortestosterone, is a unique androgen and anabolic steroid which is used in the form of injectable ester prodrugs like nandrolone decanoate. It is closely related to testosterone structurally but has a number of important pharmacological differences in comparison. These differences include inactivation by 5α-reductase rather than potentiation, less or no conversion into estradiol, and much greater progestogenic activity.
As transfeminine people also have prostate glands, the weak effects of nandrolone in the prostate are potentially of relevance to us as well. However, due to estrogen therapy and androgen deprivation, the prostate is atrophied in transfeminine people and prostate cancer is very rare (Wiki). In relation to this, the favorable prostate profile of nandrolone may be of little significance for transfeminine people.
Belgoma and colleagues 48 highlighted the molecular mechanism behind serum lipid alteration, with a downregulation http://ukorder.online/2024/12/25/understanding-oxandrolone-an-overview-of-its-uses/ of several intracellular factors that leads to the synthesis of sphingolipids and glycerolipids. AASs decrease lipogenesis by the downregulation of the activity of the lipogenic liver X receptor pathway via activation of the androgen receptor. Moreover, the androgen receptor induces de novo synthesis of fatty acids and cholesterol by upregulated HMG-CoA (steroid synthesizing enzymes in the adrenal gland—Coenzyme A) reductase and low-density lipoprotein (LDL) receptor.
At the base of the article each reference will be linked to a peer-reviewed study or paper. All Steroidal.com content is medically reviewed and fact checked to ensure as much factual accuracy as possible. If you think there has been an overdose, call your poison control center or get medical care right away. The anabolic effect on proteins requires a specific diet necessary to maintain a correct nitrogen balance.
Nandrolone
Call your doctor or get medical help if you have any side effects that bother you or do not go away. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take nandrolone with all of your drugs and health problems.
It’s not as exciting as a steroid like Dianbol that packs on size and strength seemingly in days or that provides the overall impact of excitement such as a steroid like Trenbolone. But in terms of an all around steroid, one that produces quality gains, promotes so many health benefits and produces solid results, Nandrolone will always be at the top of the list. While quality Nandrolone isn’t hard to find the primary issue of concern is and will always be legality. Nandrolone is classified as a Schedule III controlled substance by way of the Steroid Control Act of 1990. Any purchase or possession of a Schedule III drug is not legal without a prescription. An online purchase will not be a legal purchase and can come with heavy legal consequences.
People who misuse anabolic steroids like nandrolone may swallow them or rub them into their skin. Even the typical prescribed dose of nandrolone for an illness or injury (about 0.4 milligrams per kilogram of body weight a day) can have side effects like headaches, bloating, diarrhea, belly pain, jaundice, high blood pressure, and changes in menstrual cycle. Athletes often use 10 times this amount or more to boost muscle mass or performance. Anabolic steroids include testosterone and lab-grown (synthetic) forms of testosterone.
Additional research is needed to properly characterize nandrolone for this indication. The side effects on the natural synthesis of anabolic steroids play a potential role on hormonal changes/regulation and they could be suspected to be at the base of certain carcinogenic mechanisms 134,135. Furthermore, easily accessible and commonly diffused AASs, such as nandrolone and stanozolol, playa potential role in the pathogenesis of cancer, such as Leydig cell tumor, through multiple process pathways 134. Nandrolone magnified cyclin D1 concentration, inducing breast cell proliferation. Some believe that testosterone is important in women for mood, well-being, energy, sexual desire and function, general health, and for other reasons. Androgen levels and activity may be low in many transfeminine people due to hormone therapy and/or gonadectomy, raising concerns about androgen deficiency.